|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study investigated the association between plasma homocysteine, folate and vitamin B12 with 5,10 methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), thymidylate synthase (TYMS 2R → 3R) and methionine synthase (MTR A2756G) polymorphisms and methotrexate (MTX) treatment and toxicity in Tunisian Rheumatoid arthritis (RA) patients.
|
29796841 |
2018 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.
|
28994615 |
2017 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis results demonstrate that the MTHFR C677T polymorphism is involved in the genetic susceptibility of RA in Asians, and the MTHFR A1298C polymorphism is associated with genetic susceptibility to RA in the overall population.
|
27423206 |
2017 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, our meta-analysis suggested no significant effect of MTHFR gene A1298C polymorphism on MTX outcome in RA patients.
|
28544525 |
2017 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models.
|
26147289 |
2015 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis suggest that the MTHFR C677T and A1298C polymorphisms are associated with MTX toxicity in RA patients.
|
24794492 |
2014 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The available evidence suggests that the MTHFR C677T and A1298C gene polymorphisms are not reliable predictors of response to MTX treatment in RA patients.
|
21931346 |
2013 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis.
|
21773884 |
2012 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the involvement of the C677T and A1298C polymorphisms in the MTHFR gene in the toxicity of MTX in a Spanish RA population.
|
22044028 |
2012 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.
|
20514079 |
2011 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results show that the MTHFR 1298 A>C gene polymorphism confers an increased risk for subclinical atherosclerosis and CV events in patients with RA.
|
20423475 |
2010 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis including 1514 patients with RA found no association between the C677T and A1298C polymorphisms of MTHFR and the toxicity and efficacy of methotrexate in RA.
|
20067328 |
2010 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been suggested that common polymorphisms in its gene (C677T and A1298C) could be related to different methotrexate (MTX) response and toxicity in rheumatoid arthritis (RA) patients.
|
19604445 |
2009 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although RA remission rate in carriers of the MTHFR 677T and 1298C alleles was more frequently observed, it does not seem that 677C>T and 1298A>C MTHFR polymorphisms have a major influence on treatment outcome in RA patients treated with sulfasalazine.
|
19578646 |
2009 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
C667T, and to a lesser extent A1298C polymorphisms, are also reported to influence the cytotoxic effect of fluoropyrimidines and antifolates providing support for their pharmacogenetic role in predicting the efficacy and the toxicity in cancer and rheumatoid arthritis patients.
|
18781847 |
2008 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR A1298C 'C' allele incidence among RA patients (46%) was significantly higher (chi2 = 4.24, P < 0.05, OR = 1.68).
|
18274813 |
2008 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the association between 677C > T and 1298A > C MTHFR polymorphisms and arechin efficacy in the treatment of RA, a total of 50 RA patients, treated with arechin were analyzed.
|
18195462 |
2008 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States.
|
17965559 |
2007 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, the six polymorphisms associated with rheumatoid arthritis (RA), N-acetyltransferase2 (NAT2) gene polymorphisms T341C, G590A, and G857A, methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms C677T and A1298C, and serum amyloid A1 (SAA1) gene promoter polymorphism C-13T were simultaneously detected by the electrochemical DNA chip and the loop-mediated isothermal amplification (LAMP) method, which is a novel technique for DNA amplification.
|
17985847 |
2007 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the association between 677C>T and 1298A>C MTHFR polymorphisms and MTX efficacy in the treatment of RA, a total of 174 RA patients, treated with MTX plus methylprednisone 4 mg and folic acid 5 mg were analyzed.
|
18034620 |
2007 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A1298C polymorphism of the MTHFR gene may indicate a need to adjust the dose of methotrexate given to patients with rheumatoid arthritis.
|
15361376 |
2004 |