|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both <i>MTHFR</i> C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents.
|
30081597 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the subgroup stratified by region, sample size, genotyping method and source of controls, the increased risks were widely observed in both the C677T and A1298C polymorphisms with CHD risk.
|
29554656 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted an updated meta-analysis to provide comprehensive evidence on the role of MTHFR A1298C polymorphism in CHD.
|
29202788 |
2017 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the A1298C polymorphism with three diseases (coronary heart disease, breast cancer and neural tube defects fathers) was statistically significant (p < 0.05).
|
27888505 |
2017 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
An association between combined MTHFR A1298C and C677T polymorphisms and CHD was recorded in the children and their mothers.
|
23933414 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is associated with risk of CHD for Europeans.
|
21780915 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a Dutch population-based case-control study of 143 children with CHD and 186 healthy children, we investigated S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), total homocysteine (tHcy), the vitamins folate and B12 and the functional single nucleotide polymorphisms in the folate gene MTHFR 677C>T and 1298A>C.
|
20868449 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This case-control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) as risk factors for the development of DS and congenital heart defects (CHD).
|
19725133 |
2009 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease.
|
18204887 |
2009 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No evidence existed of a pharmacogenetic effect on statins with the MTHFR 1298 A>C genotype for CHD risk.
|
18622257 |
2008 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal).
|
18384842 |
2008 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
|
16268464 |
2005 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease.
|
15135689 |
2004 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence and role of methylenetetrahydrofolate reductase 677 C-->T and 1298 A-->C polymorphisms in coronary artery disease in Arabs.
|
14521457 |
2003 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease.
|
14604831 |
2003 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding.
|
11947914 |
2002 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings do not support a major role for the A1298C mutation in homocysteine metabolism and emphasize the hypothesis that MTHFR genotypes may interfere with coronary artery disease risk only when an unbalanced nutritional status leads to raised total plasma homocysteine levels.
|
12049191 |
2002 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
|
11343335 |
2001 |