|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians.
|
30813130 |
2019 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggests that the MTHFR C667T polymorphism may contribute to the genetic susceptibility to male infertility in the Chinese population, whereas MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility.
|
28081209 |
2017 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the current meta-analysis showed that the MTHFR C677T polymorphism was associated with a significantly increased male infertility risk in the Asian and overall populations, but not in the Caucasian population, and there was a significant association between the A1298C polymorphism and male infertility risk in the Asian, Caucasian, and overall groups.
|
27173242 |
2016 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no association found between the A1298C variant and male infertility.
|
25412139 |
2016 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, the MTHFR A1298C mutation was not related to male infertility.
|
26549413 |
2015 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population.
|
25966116 |
2015 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.
|
25578539 |
2015 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of this study was to examine the association between male infertility and the MTHFR (C677T and A1298C) and MTRR (A66G) polymorphisms.
|
24334125 |
2014 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
The homozygous MTHFR C677T genotype was a risk factor for male infertility</span> during 5-year follow-up, whereas a correlation between MTHFR A1298C and infertility was not observed.
|
24737513 |
2014 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio = 1.035, P = 0.56), azoospermia (Odds ratio = 0.97, P = 0.74), or oligoasthenoteratozoospermia (Odds ratio = 0.92, p = 0.29).
|
23874907 |
2013 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, we found that both 677C>T and 1298A>C polymorphisms were not significantly associated with male infertility risk.
|
21643754 |
2012 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing male infertility susceptibility, especially azoospermia.
|
22175540 |
2012 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the MTHFR A1298C variant with unexplained severe male infertility.
|
22457816 |
2012 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, we showed that homozygosity for the 677(C;T) mutation in the MTHFR gene is a risk factor for idiopathic male infertility and now we aim to assess whether the A1298C mutation in the same gene is an additional risk factor for idiopathic male infertility in an Indian population.
|
20935396 |
2010 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) genotype is associated with male infertility.
|
16247718 |
2005 |