|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD).
|
30992611 |
2020 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A1298C polymorphism contributed to prolong the duration time of schizophrenia.
|
31302825 |
2019 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR A1298C polymorphism was found to be a risk factor for schizophrenia and might have played a significant role in the pathogenesis of schizophrenia.
|
28862175 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated a significant association with SZ existed in Asian populations, not among the white populations and no significant association was detected between the MTHFR A1298C and BPD in all groups.
|
24938371 |
2015 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While MTHFR C677T and A1298C polymorphisms were not previously studied in an Arab population with respect to the susceptibility for developing schizophrenia, the MTRR A66G was not previously investigated in any population around the world.
|
22813657 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although MTHFR A1298C was not significantly associated with the combination of major psychiatric disorders, nor with SZ, there was evidence for diagnostic moderation indicating a significant association with BPD (random effects OR=2.03 for AA versus CC genotype carriers, CI: 1.07-3.86).
|
21185933 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no consistent relationship between MTHFR C677T, A1298C or combined 677T/1298C carriers and age of onset in schizophrenia when the results of each study were combined using meta-analysis.
|
21302350 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant association between either of the two polymorphisms and the risk of schizophrenia (chi-square = 0.001, df = 1, P = 0.971 for C677T; chi-square = 1.319, df = 1, P = 0.251 for A1298C).
|
22022190 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no evidence of rs1801131 (A1298C) affecting age of onset in schizophrenia.
|
19746410 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.
|
20694488 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, MTHFR A1298C genotype may explain part of the individual liability to metabolic disturbances in patients with schizophrenia.
|
20523222 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that deficient MTHFR enzyme activity in pregnant women, related to the A1298C variant, is associated with a higher risk of having offspring affected with schizophrenia.
|
20044984 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
|
17976958 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia.
|
18165967 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.
|
17074966 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia.
|
17188847 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia.
|
16641680 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate whether tHcy levels and MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors.
|
16076517 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, neither the MTHFR C677T nor the A1298C polymorphisms are associated with schizophrenia in women.
|
16084002 |
2005 |