| Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | Methylenetetrahydrofolate reductase (MTHFR) c.677C>T and c.1298A>C variants were known to be associated with prostate cancer (PCa) risk with conflicting results, because of MTHFR and nutrient status interaction in the prostate development. | 27819322 | 2016 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | The association between the MTHFR A1298C CC genotype and prostate cancer risk may vary within different populations. | 26782572 | 2015 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with pathological characteristics of prostate cancer in the Ecuadorian population. | 23459165 | 2013 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | No evidence of an association of MTHFR A1298C polymorphism with prostate cancer was found. | 22370724 | 2012 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | As for the A1298C polymorphism, there was no difference in distribution between the prostate cancer and control groups. | 20944139 | 2010 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study. | 20564317 | 2010 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | No evidence of an association of MTHFR A1298C polymorphism with prostate cancer was found. | 19223177 | 2009 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | In this study, it has been observed that C677T polymorphism of the MTHFR gene produces no statistically significant difference for T allele frequency and the genotype frequency in prostate cancer patients and male controls with benign prostate hyperplasia not having prostate cancer, whereas it has been observed that A1298C polymorphism produces a statistically significant difference for C allele frequency in prostate cancer patients and controls and that it also produces a statistically marginal significance for genotype frequencies. | 19814618 | 2009 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | Neither the MTHFR 677C-->T nor the MTHFR 1298A-->C polymorphism was statistically significantly associated with the risk of prostate cancer in univariate analysis by conditional logistic regression. | 16374229 | 2006 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | Among all study subjects, we observed no association between the C677T variant and prostate cancer but a slight positive association between the A1298C variant and risk of this disease [odds ratio (OR) 1.41, 95% confidence interval (CI) 0.96-2.06; P = 0.08]. | 15298954 | 2004 | |||||
Malignant neoplasm of prostate
|
0.100 | GeneticVariation | BEFREE | In this study we examined the C677T and A1298C polymorphisms of the MTHFR gene in specimens from 81 patients with prostate cancer and 42 controls selected from patients with benign prostatic hypertrophy (BPH). | 15492840 | 2004 |