|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the 1298A>C polymorphism in the MTHFR gene is not a risk factor for is</span>chaemic stroke in paediatric patients.
|
29396624 |
2018 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, the evidence from this meta-analysis concluded that MTHFR (677C>T and 1298A>C), eNOS (+894G>T and VNTR), PDE4D SNP 83, ACE I/D, AGT 235M>T, PON1 192Q>R, and ApoE ε2ε3ε4 polymorphisms predispose individuals to ischemic stroke.
|
28760411 |
2017 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD).
|
27629735 |
2016 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokes.
|
26951304 |
2016 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677C>T, 1298A>C, eNOS intron 4a/b, and ApoE polymorphisms were significantly associated with the increased risk of ischemic stroke.
|
26187788 |
2015 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
We concluded that the A1298C polymorphism and the haplotypes C-677-C-1298 and T-677-C-1298 in MTHFR might modulate the risk of ischemic stroke in the Eastern Chinese Han population.
|
25966188 |
2015 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
An analysis of the results obtained in this study and a critical review of previously published studies indicate that the A1298C polymorphism of the MTHFR gene is not related to ischemic stroke in children.
|
25440348 |
2015 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
After excluding articles that deviated from Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between MTHFR A1298C gen</span>etic polymorphism and risk of ischemic stroke were observed in dominant (odds ratio [OR] 1.227, 95% confidence interval [CI] 1.062-1.416) and codominant (OR 1.138, 95% CI 1.007-1.286) inheritance models.
|
24128767 |
2014 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homocysteine levels were significantly higher in IS patients with the MTHFR C677T variant (CT and TT genotypes) (P < 10(-3)); however, the difference was not significant with the MTHFR A1298C variant (AC and CC genotypes) (P = .31).
|
23642756 |
2013 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
To compare the distributions of mutations/polymorphisms in genes affecting hemostasis (factor V Leiden - FVL, FV H1298R-FVR2, FII 20210A, b-Fib 455G>A, FXIII V34L, PAI-1 4G, HPA-1b) or homocysteine metabolism (MTHFR C677T, MTHFR A1298C) among 90 children with arterial ischemic stroke (AIS) and 103 controls, and to associate the carriage of these mutations/polymorphisms with their corresponding proteins in children with AIS.
|
16567932 |
2006 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic risk factors for hamorrhagic and ischemic stroke respectively, independent of other atherothrombotic risk factors.
|
17113927 |
2006 |