Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis. 30131855 2018
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy. 28044213 2017
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. 26156333 2016
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer. 26111049 2015
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorectal cancer risk in the Turkish population. 25292054 2014
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We evaluated the associations between plasma folate, MTHFR C677T, and A1298C, and colorectal cancer in three large prospective studies: the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians' Health Study. 22367721 2012
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C with risk for colorectal cancer in an eastern Chinese Han population of 137 patients with a confirmed histopathological diagnosis of CRC and 145 age- and gender-matched controls with no history of cancer. 22194208 2011
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy. 19669769 2010
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients. 20193847 2010
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We related prediagnostic plasma folate, vitamin B12, and total homocysteine concentrations, and the MTHFR 677C>T and 1298A>C polymorphisms, to the risk of colorectal cancer with and without the CpG island methylator phenotype (CIMP). 20012180 2010
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE To study the relation between genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C and the susceptibility of colorectal cancer. 18712959 2009
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. 20076818 2009
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. 19156174 2009
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The available evidence indicates that MTHFR C677T and A1298C gene polymorphisms cannot be considered as reliable predictors of response to fluorouracil-based chemotherapy in patients with colorectal cancer. 19663673 2009
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activity and have been associated with reduced risk for a variety of cancers such as acute lymphocytic leukemia, lung and colorectal cancer. 18804702 2008
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We report a population-based case-control study of folate intake, related dietary factors and MTHFR polymorphisms (C677T, A1298C) and colorectal cancer in a population with relatively high colorectal cancer incidence and relatively low folate intake. 18053312 2008
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis. 17089070 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE C667T and A1298C mutations represent a risk factor for colorectal cancer with an OR (odds ratio) = 2.13 (CI (0.51-8.91)) and 3 (CI(0.3-29.58), respectively, in homozygous patients. 17925917 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We investigated the association of C677T and A1298C, two common polymorphisms in the methylenetetrahydrofolate reductase gene, with risk for early onset colorectal cancer in Lynch syndrome. 17855693 2007
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE While the A1298C polymorphism showed no measurable association with the overall risk of colorectal cancer, the 1298CC genotype was associated with a statistically significant increase in the risk when alcohol consumption was high, and was also associated with an approximately 2-fold increase in the risk of each of proximal and distal colon cancer. 15546509 2004
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Whereas our results do not support an association of high enzyme activity and increased risk of colorectal cancer in general, we can not exclude an association of patients with hereditary disease and the MTHFR 1298A --> C variant. 12618331 2003
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism. 12042673 2002
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE This population-based case-control study was designed to investigate the interrelationships between polymorphisms in the methylenetetrahydrofolate (MTHFR C677T and A1298C) gene and other genes (MTR A2756G; MTRR A66G and CBS 844ins68), intake of B-vitamins and colorectal cancer risk (CRC). 12020105 2002