|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings provide further evidence supporting rs401681 as a genetic variant associated with the risk of lung cancer.
|
24386361 |
2013 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings provide further evidence supporting rs401681 as a genetic variant associated with the risk of lung cancer.
|
24386361 |
2013 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We genotyped rs2736100 (TERT) and rs401681 (CLPTM1L) SNPs in a case-control study with 399 lung cancer cases and 466 controls form Taiyuan, China.
|
23433592 |
2013 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The results from our case-control study and meta-analysis provide convincing evidence that rs401681 is significantly associated with lung cancer risk.
|
23653681 |
2013 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer.
|
29033187 |
2017 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
No association was found between CLPTM1L-rs401681 and lung cancer risk.
|
24861918 |
2014 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
Carcinoma, Basal Cell
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
Carcinoma, Basal Cell
|
|
0.740 |
GeneticVariation
|
BEFREE |
In individuals with a risk allele at either rs1805007 or rs401681 the median time to BCC</span> was 31 years of age (95% CI: 28-34) compared with 44 years of age (95% CI: 38-53) in wild-type individuals (HR=2.48, 95% CI: 1.47-4.17, P=0.0002).
|
25159867 |
2015 |
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
|
Carcinoma, Basal Cell
|
|
0.740 |
GeneticVariation
|
BEFREE |
We evaluated the associations between 39 SNPs, including 38 tag-SNPs in telomere-related genes (TERT, TRF1, TRF2, TNKS2, and POT1) and one SNP (rs401681) in the TERT-CLPTM1L locus which has been identified as a susceptibility locus to skin cancer in the previous GWAS, and the risk of skin cancer in a case-control study of Caucasians nested within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.
|
21116649 |
2011 |
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
|
25284078 |
2015 |
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33.
|
25940397 |
2015 |
|
Carcinoma, Basal Cell
|
|
0.740 |
GeneticVariation
|
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33.
|
25940397 |
2015 |
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
|
25284078 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
We found that the rs401681C/T allele in the TERT-CLPTM1L gene was associated with the risk of non-small cell lung cancer [NSCLC; P = 0.012, odds ratio (OR) = 1.29, 95% confidence interval (95%CI) = 1.09-1.50], but was not associated with the risk of small cell lung cancer (P = 0.571, OR = 1.15, 95%CI = 0.82-1.47).
|
23359026 |
2013 |