Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.