rs4149056, SLCO1B1

N. diseases: 45
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diarrhea
CUI: C0011991
Disease: Diarrhea
0.030 GeneticVariation BEFREE Of these, 19 sets gave relatively good description of the effect of UGT1A1 *28 and SLCO1B1 c.521T>C polymorphism on the SN-38 plasma concentration, neutropenia, and diarrhea observed in clinical studies reported mainly by Teft et al.(Br J Cancer.112(5):857-65, 20). 28397089 2017
Diarrhea
CUI: C0011991
Disease: Diarrhea
0.030 GeneticVariation BEFREE Meta-analysis showed east-Asian patients expressing SLCO1B1 521T>C or 1118G>A to have a two- to fourfold increased risk of irinotecan-induced neutropenia but not diarrhea. 27380948 2016
Diarrhea
CUI: C0011991
Disease: Diarrhea
0.030 GeneticVariation BEFREE Polymorphisms in SLCO1B1 (rs2306283, rs4149056) were associated with diarrhea and thrombocytopenia, respectively. 27533851 2016