|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
The data highlight the role of SLCO1B1 c.521C>T SNP as a replicable genetic risk factor for statin myop</span>athy.
|
31220337 |
2019 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
GWASCAT |
The data highlight the role of SLCO1B1 c.521C>T SNP as a replicable genetic risk factor for statin myopathy.
|
31220337 |
2019 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
Statin-induced myopathy has been linked to the C allele of a single nucleotide polymorphism (SNP) (rs4149056) of SLCO1B1 gene.
|
29534995 |
2018 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
Statin-induced myopathy is reported to be significantly associated with the SCLO1B1 c.521T>C polymorphism.
|
29969773 |
2018 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
The findings of this study indicated that SLCO1B1 T521C was associated with a significantly higher risk of statin-induced myopathy, especially for simvastatin, rosuvastatin, and cerivastatin.
|
30250148 |
2018 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
The available evidence suggests that SLCO1B1 gene T521C polymorphism is associated with an increased risk of statin-related myopathy, especially in individuals receiving simvastatin.
|
26376374 |
2015 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
Meta-analysis showed an association between c.521C>T and simvastatin-induced myopathy, although power for other statins was limited.
|
23942138 |
2013 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
However, when subjects were stratified by statin type, the SLCO1B1 rs4149056</span> genotype was significantly associated with myopathy in patients who received simvastatin, but not in patients who received atorvastatin.
|
21243006 |
2012 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group.
|
21992719 |
2011 |
|
Myopathy
|
|
0.790 |
GeneticVariation
|
BEFREE |
The association of rs4149056 with myopathy was replicated in the trial of 40 mg of simvastatin daily, which also showed an association between rs4149056 and the cholesterol-lowering effects of simvastatin.
|
18650507 |
2008 |
|
Finding of Mean Corpuscular Hemoglobin
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Uric acid measurement (procedure)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
|
31578528 |
2019 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Thyroxine measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Sex hormone binding globulin measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8 × 10(-106)), PRMT6 (rs17496332, 1p13.3, p = 1.4 × 10(-11)), GCKR (rs780093, 2p23.3, p = 2.2 × 10(-16)), ZBTB10 (rs440837, 8q21.13, p = 3.4 × 10(-09)), JMJD1C (rs7910927, 10q21.3, p = 6.1 × 10(-35)), SLCO1B1 (rs4149056, 12p12.1, p = 1.9 × 10(-08)), NR2F2 (rs8023580, 15q26.2, p = 8.3 × 10(-12)), ZNF652 (rs2411984, 17q21.32, p = 3.5 × 10(-14)), TDGF3 (rs1573036, Xq22.3, p = 4.1 × 10(-14)), LHCGR (rs10454142, 2p16.3, p = 1.3 × 10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7 × 10(-08)), and UGT2B15 (rs293428, 4q13.2, p = 5.5 × 10(-06)).
|
22829776 |
2012 |
|
Squamous cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
|
Estradiol level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
22829776 |
2012 |
|
Estradiol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
22829776 |
2012 |
|
Bilirubin level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association between <i>SLCO1B1</i> rs4149056 and tegafur-uracil-induced hepatic dysfunction in breast cancer.
|
30734632 |
2019 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
<b>Patients & methods:</b> Postmenopausal women with hormone-receptor positive breast cancer were genotyped for <i>SLCO1B1*5</i> (rs4149056) and rs10841753.
|
31190621 |
2019 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association between <i>SLCO1B1</i> rs4149056 and tegafur-uracil-induced hepatic dysfunction in breast cancer.
|
30734632 |
2019 |