rs4263839, TNFSF15

N. diseases: 7
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.830 GeneticVariation BEFREE Among the TNFSF15 SNPs, rs4263839 associated with CD in Taiwan (P = 0.005), haplotype analysis did not increase the association. 24783249 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.830 GeneticVariation BEFREE This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility. 25028192 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.830 GeneticVariation BEFREE The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample. 21636646 2011
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.830 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.830 GeneticVariation GWASCAT Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364 2011
Asthma
CUI: C0004096
Disease: Asthma
0.700 GeneticVariation GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. 31615448 2019
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE Our meta-analysis could not confirm a major role of most investigated SNPs, but a moderate association between rs4263839 TNFSF15 and IBS, in particular IBS-C. 25824902 2015
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample. 21636646 2011
Diverticulitis
CUI: C0012813
Disease: Diverticulitis
0.010 GeneticVariation BEFREE A second haplotype, rs6478108 (A), rs6478109 (G), rs7869487 (A), and rs4263839 (G), was also associated with DD in this cohort (P = 0.025). 28624054 2017
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.010 GeneticVariation BEFREE This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility. 25028192 2014
Constipation
CUI: C0009806
Disease: Constipation
0.010 GeneticVariation BEFREE The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample. 21636646 2011