|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
IGF2BP2 variants rs4402960 and rs1470579 were not associated with type 2 diabetes in the present study (P = 0.632 and P = 0.896, respectively).
|
18430866 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples.
|
24736664 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
|
24898818 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyse the association between PPARG rs1801282, PPARGC1A rs8192678, VEGFA rs2010963, ADRA2A rs553668, KCNQ1 rs2237892, SIRT1 rs7896005, IGF2BP2 rs4402960, and UCP3 rs3781907 single nucleotide variants (SNVs) with T2D and metabolic traits in a case-control study of a population from Mexico City.
|
29800730 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The analyses showed that age (P < 0.0001), BMI (P < 0.0001), and six variants (IGF2BP2 rs4402960, P = 0.002; ADIPOQ+276 G>T, P = 0.004; UCP2Ala55Val, P = 0.01; CDKN2AI2B rs3731201, P = 0.02; rs495490, P = 0.02, and rsl 0811661, P = 0.03) were significantly associated with the risk of IFG/IGT/T2DM.
|
20384434 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.
|
25755232 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We replicated an association between rs4402960 and T2D status, and reported significant associations with anthropometric traits, fasting insulin, HOMA-IR and HOMA-%B.
|
20627640 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
|
22923468 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The present study provided data suggesting that the wild C allele of IGF2BP2 (rs4402960) had a protective effect against T2DM in obese subjects of Chinese Han population.
|
25062844 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The IGF2BP2 gene rs1470579 and rs4402960 polymorphisms were associated with T2DM and therapeutic efficacy of pioglitazone in this Chinese population.
|
25247335 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The present study has replicated the association of IGF2BP2 rs4402960 with T2D in the Czech population and provided data suggesting that IGF2BP2 may have genetic interaction with IGF2 with a protective effect against DN in male patients with T1D.
|
22770937 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We validate that IGF2BP2 susceptibility variants rs4402960 and rs1470579 associate with T2DM in Lebanese Arabs.
|
22245690 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 35 studies involving a total of 175,965 subjects for two wildly studied polymorphisms (rs4402960 and rs1470579) of the IFG2BP2 to evaluate the effect of IFG2BP2 on genetic susceptibility for T2D.
|
22015911 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Patients with schizophrenia have an increased prevalence of type 2 diabetes mellitus, and type 2 diabetes mellitus has shown an association with the rs4402960 gene polymorphism in the insulin-like growth factor II messenger RNA (mRNA)-binding protein 2 gene (IGF2BP2).
|
23656854 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The meta-analysis also showed the association between T2DM and IGF2BP2 (rs1470579 OR of 1.15 (95% CI = 1.10-1.19), P < 0.0001 under an additive model and rs4402960 OR of 1.14 (95% CI = 1.10-1.18), P < 0.0001 under an additive model).
|
24229666 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant.
|
17827400 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634).
|
19033397 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of T2DM, and these polymorphisms may affect the therapeutic efficacy of repaglinide in Chinese T2DM patients.
|
20523342 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that rs4402960 polymorphism in IGF2BP2 is associated with elevated T2D risk, but these associations vary in different ethnic populations.
|
22032244 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that IGF2BP2 rs4402960 polymorphism conferred elevated risk of T2DM, especially in European, East Asian and South Asian populations.
|
21839790 |
2011 |