Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
Application of our method to a breast cancer susceptibility region in 5p12 demonstrates that the risk allele rs4415084-T correlates with higher expression levels of the protein-coding gene mitochondrial ribosomal protein S30 (<i>MRPS30</i>) and lncRNA <i>RP11-53O19.1</i> We propose an intergenic SNP rs4321755, in linkage disequilibrium (LD) with the GWAS SNP rs4415084 (<i>r</i><sup>2</sup> = 0.988), to be the predicted functional SNP.
|
29351903 |
2018 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs10941679-G allele and rs4415084-T allele might be risk-conferring factors for the development of breast cancer, especially in Caucasians and East-Asians.
|
24039999 |
2013 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer were observed for rs13387042 and rs4415084 with OR (95% CI) per-allele 1.29 (1.00-1.66) and 0.83 (0.71-0.97), respectively.
|
27022606 |
2016 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
We confirmed the reported association of rs4415084 SNP with overall risk of breast cancer (P = 0.06), and, as in the original study, observed a stronger association with estrogen receptor positive tumors (P = 0.03).
|
20140701 |
2010 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
A genome-wide association study, conducted among women of European ancestry, has identified two single-nucleotide polymorphisms (SNPs) rs4415084 (T>C) and rs10941679 (A>G) at chromosome 5p12 were associated with risk of breast cancer, suggesting that genetic variants in this region may have a role in the development of breast cancer.
|
22832384 |
2012 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
After that, a number of studies reported that the rs10941679, rs4415084, and rs981782 polymorphism in chromosome 5p12 has been implicated in BC risk.
|
23977236 |
2013 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
In exploratory analyses, we found that the radiation-associated breast cancer risk varied significantly by linked markers in 5p12 (rs930395, rs10941679, rs2067980 and rs4415084) in the mitochondrial ribosomal protein S30 (MRPS30) gene (P(interaction) = 0.04).
|
20095854 |
2010 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679).
|
18438407 |
2008 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
BEFREE |
This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs.
|
29372690 |
2017 |
Malignant neoplasm of breast
|
|
0.790 |
GeneticVariation
|
GWASDB |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |