rs4570625, TPH2

N. diseases: 25
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD. 27807918 2017
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events. 26386440 2015
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models. 22693556 2012
Anxiety symptoms
CUI: C0860603
Disease: Anxiety symptoms
0.020 GeneticVariation BEFREE TPH2 rs4570625 GG carriers were more likely to achieve depressive and anxiety symptom remission compared with T-allele carriers. 26745768 2016
Anxiety
CUI: C0003467
Disease: Anxiety
0.020 GeneticVariation BEFREE Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011). 26232682 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.020 GeneticVariation BEFREE Exploratory analysis of genotypes in currently dependent patients showed that rs1843809 was associated with depressive and aggressive traits (p=0.045 and p=0.001, respectively), rs4290270 with depressive and anxiety traits (p=0.040 and p=0.025, respectively) and rs4570625 with aggressive traits (p=0.011). 26232682 2015
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.020 GeneticVariation BEFREE In this study involving 64 individuals, we examined the associations between prefrontal cortical GABA concentration and 12 single nucleotide polymorphisms (SNPs) spanning the TPH2 gene, including rs4570625 (-703 G/T SNP), a potentially functional TPH2 polymorphism that has been associated with decreased TPH2 mRNA expression and panic disorder. 23552096 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.020 GeneticVariation BEFREE Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety. 22835848 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.020 GeneticVariation BEFREE Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety. 22835848 2013
Attention deficit hyperactivity disorder
0.020 GeneticVariation BEFREE Here we investigated the influence of the ADHD related risk alleles for rs4570625 and for rs11178997 on prefrontal brain function during cognitive response control in large samples of adult ADHD patients (n=124) and healthy controls (n=84). 18427560 2009
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.020 GeneticVariation BEFREE Moreover, rs4570625 may have a gender-dependent effect on susceptibility to PD. 19132526 2009
Anxiety symptoms
CUI: C0860603
Disease: Anxiety symptoms
0.020 GeneticVariation BEFREE However, a haplotype that included the promoter rs4570625 polymorphism (associated with anxiety-related traits in previous studies) showed an association with the severity of anxiety symptoms on admission. 19361870 2009
Attention deficit hyperactivity disorder
0.020 GeneticVariation BEFREE Haplotype analysis revealed a strong trend of association between the regulatory region SNPs (rs4570625, rs11178997) and ADHD (P=0.064). 16116490 2005
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.010 GeneticVariation BEFREE Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>. 31817010 2019
Fatigue
CUI: C0015672
Disease: Fatigue
0.010 GeneticVariation BEFREE Only one SNP, TPH2 rs4570625, was significantly associated with fatigue ( p = .005). 30309244 2019
Drug habituation
CUI: C0013170
Disease: Drug habituation
0.010 GeneticVariation BEFREE While effects of 5-HTTLPR and of a serotonergic multi-marker score (5-HTTLPR, TPH1(rs1800532), TPH2(rs4570625), HTR1A(rs6295) and HTR2A(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, DLPFC, and ACC. 29358097 2018
Impulsive Behavior
CUI: C0021125
Disease: Impulsive Behavior
0.010 GeneticVariation BEFREE Subjects with the TPH2 rs4570625 TT genotype, especially males, exhibit less aggression and a favourable impulsivity profile, and develop anxiety disorders by young adulthood less often. 28342337 2017
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.010 GeneticVariation BEFREE We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample. 28342337 2017
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.010 GeneticVariation BEFREE We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample. 28342337 2017
Oppositional Defiant Disorder
CUI: C0029121
Disease: Oppositional Defiant Disorder
0.010 GeneticVariation BEFREE Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups. 27871272 2016
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.010 GeneticVariation BEFREE Individuals carrying the T(-) genotype of rs4570625 (GG), T(-) genotype of rs11178997 (AA), or A(-) genotype of rs120074175 (GG) were susceptible to MD only when exposed to high-negative life events. 26386440 2015
Epilepsy, Temporal Lobe
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
0.010 GeneticVariation BEFREE We assessed the influence of the rs4570625 and rs17110747 polymorphisms in the TPH2 gene on psychiatric comorbidities in TLE. 24491795 2014
Alcohol abuse
CUI: C0085762
Disease: Alcohol abuse
0.010 GeneticVariation BEFREE More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE. 24491795 2014
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.010 GeneticVariation BEFREE In patients with TLE, the presence of the T allele in the rs4570625 polymorphism was associated with psychotic disorders (OR=6.28; 95% CI=1.27-17.54; p=0.02), while the presence of the A allele in the rs17110747 polymorphism was associated with alcohol abuse (OR=20.33; 95% CI=1.60-258.46; p=0.02). 24491795 2014
Tic disorder
CUI: C0040188
Disease: Tic disorder
0.010 GeneticVariation BEFREE Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys. 23360517 2013