rs4633, COMT;MIR4761

N. diseases: 13
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASDB Genome wide association study: searching for genes underlying body mass index in the Chinese. 24827717 2014
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASDB Genome wide association study: searching for genes underlying body mass index in the Chinese. 24827717 2014
Pain
CUI: C0030193
Disease: Pain
0.020 GeneticVariation BEFREE In the overall sample, rs4633 and rs4680 were significantly associated with morphine use, whereas rs4818 was associated with time-averaged pain scores. 25963335 2016
Pain
CUI: C0030193
Disease: Pain
0.020 GeneticVariation BEFREE Our results reveal that the alleles of each SNP are not significantly correlated with pain perception except for the rs4633 allele in the 2 Hz TEAS session (P < 0.05). 22253202 2012
Agnosia for Pain
CUI: C0563625
Disease: Agnosia for Pain
0.010 GeneticVariation BEFREE Statistically significant associations were found between COMT rs4633 and rs4680 genotypes and the amount of morphine self-administered through a patient-controlled analgesia pump. 25963335 2016
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.010 GeneticVariation BEFREE However, COMT: rs4680: A>G and rs4633: C>T polymorphisms were found to significantly affect PD risk, and the MTHFR 677C>T polymorphism helped determine plasma Hcy concentrations. 22890010 2013
Low Back Pain
CUI: C0024031
Disease: Low Back Pain
0.010 GeneticVariation BEFREE A nonsignificant trend was observed between SNP rs4633 and greater improvement in VAS score for LBP. 20863768 2011
Bulimia Nervosa
CUI: C2267227
Disease: Bulimia Nervosa
0.010 GeneticVariation BEFREE This study aimed to (1) examine if certain variants of the COMT genetic markers (rs6269, rs4633, rs4818 and rs4680) are more common in BN versus controls; (2) assess transmission of COMT alleles in BN families; and (3) explore the role of COMT genotypes and haplotypes in bulimic women with childhood ADHD history. 21300128 2011
Paranoid Schizophrenia
CUI: C0036349
Disease: Paranoid Schizophrenia
0.010 GeneticVariation BEFREE The major findings of this study were that, among the individuals carrying the rs3751082 A allele in the ALDH3B1 gene, the rs4633 T allele in the COMT gene was associated with susceptibility to paranoid schizophrenia (p = .004), development of hallucination (p = 5.141 E-5), delay of P300 latency in both patients (p = .006) and control subjects (p = .02), and increased expression of the COMT gene in control subjects (p = .002). 19159868 2009
Hallucinations
CUI: C0018524
Disease: Hallucinations
0.010 GeneticVariation BEFREE The major findings of this study were that, among the individuals carrying the rs3751082 A allele in the ALDH3B1 gene, the rs4633 T allele in the COMT gene was associated with susceptibility to paranoid schizophrenia (p = .004), development of hallucination (p = 5.141 E-5), delay of P300 latency in both patients (p = .006) and control subjects (p = .02), and increased expression of the COMT gene in control subjects (p = .002). 19159868 2009
Malignant neoplasm of endometrium
CUI: C0007103
Disease: Malignant neoplasm of endometrium
0.010 GeneticVariation BEFREE DNA samples from 150 cases of EC and healthy controls (n = 165) were analyzed by PCR-RFLP to determine the genotypic frequency of four different polymorphic loci on COMT [codon 62 (rs4633), 102 (rs5031015), 136 (rs4818), 158 (rs4680)]. 18324659 2008
Uterine Corpus Cancer
CUI: C1883486
Disease: Uterine Corpus Cancer
0.010 GeneticVariation BEFREE DNA samples from 150 cases of EC and healthy controls (n = 165) were analyzed by PCR-RFLP to determine the genotypic frequency of four different polymorphic loci on COMT [codon 62 (rs4633), 102 (rs5031015), 136 (rs4818), 158 (rs4680)]. 18324659 2008
Endometrial Carcinoma
CUI: C0476089
Disease: Endometrial Carcinoma
0.010 GeneticVariation BEFREE DNA samples from 150 cases of EC and healthy controls (n = 165) were analyzed by PCR-RFLP to determine the genotypic frequency of four different polymorphic loci on COMT [codon 62 (rs4633), 102 (rs5031015), 136 (rs4818), 158 (rs4680)]. 18324659 2008
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.010 GeneticVariation BEFREE The Val/Met and rs4633 variants showed nominally significant associations with SZ (P<0.05), although neither of the individual SNPs remained significant after adjusting for multiple testing (most significant P=0.1174). 15505638 2005