rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity. 15450911 2004
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. 15584875 2004
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health. 15900225 2005
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (ie low extraversion and high neuroticism) is unlikely to be wholly accounted for by the well-studied rs4680 ('val/met') polymorphism. 15956988 2005
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria. 17079080 2006
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. 17146014 2006
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adolescence: results from the Victorian Adolescent Health Cohort Study. 17504250 2007
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness and magnitude; eg the functional Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls. 17805313 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. 18578865 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals. 18729643 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 19582565 2009
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. 19944409 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. 22387174 2012
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815 2012
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. 23026378 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns = 476 and 409). 23475824 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The interaction of early life experiences with COMT val158met affects anxiety sensitivity. 24118915 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE This meta-analysis provides evidence for sex and ethnic differences in the association of the COMT val158met polymorphism with anxiety traits. 24300663 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment (N=97 females: 24 Val/Val, 51 Val/Met, and 22 Met/Met). 25238960 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Based on haplotype trend regression analysis, findings also showed that among rs737865-val158met-rs165599 haplotypes, the A-val-G (AGG) haplotype probabilities modulated positive associations of antenatal maternal anxiety with cortical thickness in the right ventrolateral prefrontal cortex and the right superior parietal cortex and precuneus. 25320962 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Thus, our results provide further evidence that 5-HTTLPR and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms. 25455425 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Applying a multilevel approach, we analyzed the main and interactive effects of the functional COMT val158met polymorphism and L-dopa (single-dose 50 mg levodopa and 12.5 mg carbidopa; double-blind, placebo-controlled design) on the emotion-potentiated (unpleasant, neutral, and pleasant IAPS pictures) startle response as an intermediate phenotype of anxiety in a sample of 100 healthy probands (f = 52, m = 48). 25510857 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We also found a significant interaction effect of COMT met alleles (β = -32.5 SE 14.1, P = 0.021). in patients genotyped for COMT val158met (N  = 87) specifically COMT × conscientiousness (β = 0.73 SE 0.26, P = 0.0042) and COMT × anxiety (β = -0.42 SE 0.16, P = 0.0078) interaction effects. 25722948 2015