rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. 17522626 2008
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) is associated with lower enzymatic activity than the Val allele and is reported to be associated with aggression, depression, and suicidal behavior. 18828035 2008
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. 18578865 2008
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Although the current study found no association between COMT Val(158)Met polymorphism on a number of clinical neuropsychological tests that are typically found to be sensitive to depression, differential effects of the COMT Val(158)Met polymorphism on dopamine transmission in psychiatric and non-psychiatric populations may be further clarified by clinical research with neuroscience-based paradigms that segregate cognitive tasks into component processes with precise neural substrates, particularly with respect to the complex functions of the prefrontal cortex. 19296553 2009
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE We found that the COMT val158met polymorphism was not associated with 4-week fluoxetine therapeutic response; however, association analysis showed that patients with the COMT(Val/Val) genotype had poorer responses in the eighth week (CLUMP T1 P=0.020) and consistently showed significantly smaller reductions in HAM-D(21) scores in the eighth week (P=0.027). 18533273 2009
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation. 20403637 2010
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE There is strong evidence for a genetic contribution to the pathogenesis of depression, with the functional catechol-O-methyltransferase (COMT) val158met polymorphism having been suggested as a potential susceptibility factor. 19309019 2010
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed with repeated measures ANOVA in the context of General Linear Model, with rs4680 and fluvoxamine plasma levels as factors. 20619611 2010
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The Met-variants of COMT Val(158)Met are risk variants for depression and low motivational level in depressed Swedish men, but not women. 20828831 2011
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The functional catechol-O-methyltransferase (COMT) val158met polymorphism has been found to be associated with anxiety disorders and depression as well as with neural correlates of emotional processing, with, however, contradictory results. 22387174 2012
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. 23475824 2013
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Variation in the Catechol-O-Methyltransferase (COMT) gene, the Val158Met polymorphism in particular, has been extensively investigated in relation to clinical phenotypes of depression and, in parallel, neurocognitive processes. 23792050 2013
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE No differences in the years with pain (P = 0.954), age (P = 0.740), depression (P = 0.530), severity of CTS (P = 0.744) or presence of unilateral-bilateral symptoms (P = 0.279) existed depending on the rs4680 Val158Met genotype. 24077209 2014
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT Val158Met polymorphisms, which have been associated with risk for depression, on biases in endorsement of and memory for positive and negative adjectives. 24679392 2014
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE This exploratory study examined the association between exposure to stressful life events, polymorphisms (rs165774 and rs4680) in the catechol-O-methyltransferase (COMT) gene, and risk of depression in women. 27347613 2016
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE At 12 months, among those with depression, Met homozygotes (Val158Met) self-reported worse behavior than Val carriers (P = .015), and A2 homozygotes (Taq1a) self-reported worse behavior than A1 carriers (P = .028) in bivariable analysis. 27154305 2016
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE We concluded that depression and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT" genotype contribute to pain in PD patients. 28740224 2017
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. 28416295 2017
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019