rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. 28635556 2017
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions. 27052366 2016
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined. 29941295 2018
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. 28142064 2017
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis. 29444152 2018
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P. 16837108 2007
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. 18407467 2008
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. 16476412 2006
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17). 18351593 2008
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype. 22128864 2012
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder. 9352569 1997
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of psychotic disorders. 21231925 2011
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. 30084963 2019
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025). 17640440 2007
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE No statistically significant results were found in meta-analysis but one study reported that the rs4680 Val allele was associated with AD-related psychosis. 22483294 2012
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms. 17525974 2008
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both neuropsychological performance and brain structure in patients with psychosis, in their relatives and in healthy individuals (step 1). 23527885 2013
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene influences prefrontal cognitive function and increases the risk for schizophrenia. 15169701 2004
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the phenotypic expression of first episode psychosis at onset. 18092319 2008
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis. 20493536 2010
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated. 21947654 2011
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032 2013
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition. 16936704 2006
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics. 16969277 2006
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Differential sensitivity to environmental stress occasioned by COMT Val158Met may be contingent on higher order interactions with genetic variation underlying psychotic disorder. 21073668 2011