rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder. 23618651 2013
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity. 26803486 2016
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. 15583702 2005
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. 17522626 2008
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. 26813412 2016
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. 19520435 2010
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial. 23706899 2013
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772 2014
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression. 19309019 2010
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). 21600957 2011