|
22q11 Deletion Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM.
|
21465565 |
2011 |
|
22q11 Deletion Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.
|
16513880 |
2006 |
|
Ablepharon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neurotypical (N = 91) adults were genotyped for the COMT Val158Met polymorphism, completed the Schizotypal Personality Questionnaire (SPQ), and had eyes open resting-state EEG recorded for 4 min.
|
30084963 |
2019 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, preferential transmission of COMT rs4680 A allele and A-A haplotype (P<0.05) was observed specifically in male IID probands without any behavioral problem.
|
21609749 |
2011 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele.
|
18384078 |
2008 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.
|
21231925 |
2011 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT Val158Met genotype as a risk factor for problem behaviors in youth.
|
20643317 |
2010 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
|
28608575 |
2018 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
|
24708432 |
2014 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages.
|
22070166 |
2012 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior.
|
21486391 |
2011 |
|
Acute onset pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.
|
25102390 |
2014 |
|
Addictive Behavior
|
|
0.040 |
GeneticVariation
|
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
Addictive Behavior
|
|
0.040 |
GeneticVariation
|
BEFREE |
We have previously found an association with rs4680 and MAMP addiction.
|
21934638 |
2011 |
|
Addictive Behavior
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women.
|
16499480 |
2006 |
|
Addictive Behavior
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.
|
23288874 |
2013 |
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of NSCLC, especially ADC, which suggests that this SNP may have a protective effect.
|
22658813 |
2013 |
|
Affective Disorders, Psychotic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis.
|
18407467 |
2008 |
|
Affective Disorders, Psychotic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis.
|
20591499 |
2011 |
|
Affective Disorders, Psychotic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications.
|
20493536 |
2010 |
|
Affective Disorders, Psychotic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis.
|
18092319 |
2008 |