rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cockayne Syndrome, Type I
CUI: C0751039
Disease: Cockayne Syndrome, Type I
0.010 GeneticVariation BEFREE This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA. 31142902 2020
Autistic behavior
CUI: C0856975
Disease: Autistic behavior
0.010 GeneticVariation BEFREE Within autistic subjects, Val158Met rs4680 carriers were significantly distributed (71.2% P = 0.014) accompanied with abnormal dopamine, abnormal Electroencephalogram (EEG) and increasing the severity of autistic behaviour. 31586564 2020
Rest pain
CUI: C0234253
Disease: Rest pain
0.010 GeneticVariation BEFREE Individuals with the COMT rs4680 minor allele reported lowered pain at rest after TENS (β = -42.30; p = .001), with a higher magnitude of pain reduction (28 unit difference) in the low-frequency TENS group compared to the high-frequency TENS group (β = 28.37; p = .0004). 31661578 2020
Cockayne Syndrome, Type I
CUI: C0751039
Disease: Cockayne Syndrome, Type I
0.010 GeneticVariation BEFREE This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA. 31142902 2020
Hyperalgesia
CUI: C0020429
Disease: Hyperalgesia
0.010 GeneticVariation BEFREE Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain. 31041874 2020
Sleep Apnea, Central
CUI: C0520680
Disease: Sleep Apnea, Central
0.010 GeneticVariation BEFREE This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA. 31142902 2020
Sleep Apnea, Central
CUI: C0520680
Disease: Sleep Apnea, Central
0.010 GeneticVariation BEFREE This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA. 31142902 2020
Sensory neuropathy
CUI: C0151313
Disease: Sensory neuropathy
0.010 GeneticVariation BEFREE Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy. 31021849 2019
Frequent episodic tension-type headache
0.010 GeneticVariation BEFREE The aims of this study were: (1) to investigate the association between the rs4680 Val158Met polymorphism in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH); and (2) to analyze the association between the rs4680 Val158Met polymorphism with clinical, psychological, or psychophysical variables. 30614828 2019
Transformed migraine
CUI: C1960870
Disease: Transformed migraine
0.010 GeneticVariation BEFREE The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype. 30481348 2019
Cannabis Abuse
CUI: C0006868
Disease: Cannabis Abuse
0.010 GeneticVariation BEFREE Patients were assessed for neurocognitive measures with a broad battery, genotyped for COMT Val158Met polymorphism from peripheral blood sample, and evaluated with a semi-structured interview in order to establish the history of cannabis abuse. 30790675 2019
Alcohol Use Disorder
CUI: C0001956
Disease: Alcohol Use Disorder
0.010 GeneticVariation BEFREE Five single nucleotide polymorphisms (SNPs) (rs4532 in DRD1, rs2283265 in DRD2, rs6280 in DRD3, rs1800497 in ANKK1, and rs4680 in COMT) and a variable number of tandem repeats (VNTRs) in DAT1 in 295 male patients with AUD were genotyped. 31559529 2019
Ablepharon
CUI: C0266574
Disease: Ablepharon
0.010 GeneticVariation BEFREE Neurotypical (N = 91) adults were genotyped for the COMT Val158Met polymorphism, completed the Schizotypal Personality Questionnaire (SPQ), and had eyes open resting-state EEG recorded for 4 min. 30084963 2019
Leukemia, T-Cell
CUI: C0023492
Disease: Leukemia, T-Cell
0.010 GeneticVariation BEFREE We used polymerase chain reaction to genotype the rs4680 (Val158Met) and rs4633 (His62His) variants in the catechol-O-methyltransferase gene and rs2369049 (A > G) and rs7158782 (A > G) variants in the T-cell leukemia/lymphoma 1 A gene. 29912452 2019
Arthralgia
CUI: C0003862
Disease: Arthralgia
0.010 GeneticVariation BEFREE Specific genetic variations at loci rs4680 and rs2369049 are associated with response to acupuncture-type intervention for management of arthralgia. 29912452 2019
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.010 GeneticVariation BEFREE The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. 30840133 2019
Drug usage
CUI: C0242510
Disease: Drug usage
0.010 GeneticVariation BEFREE Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes. 31150143 2019
Verbal hallucinations
CUI: C2721589
Disease: Verbal hallucinations
0.010 GeneticVariation BEFREE COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions. 30712251 2019
Tension Headache
CUI: C0033893
Disease: Tension Headache
0.010 GeneticVariation BEFREE The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype. 30614828 2019
Episodic tension-type headache
CUI: C0393737
Disease: Episodic tension-type headache
0.010 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
Alexithymia
CUI: C0002020
Disease: Alexithymia
0.010 GeneticVariation BEFREE The findings suggest that the 5-HTTLPR and COMT Val158Met polymorphisms are not associated with alexithymia. 30707988 2019
Hypoalgesia
CUI: C0085625
Disease: Hypoalgesia
0.010 GeneticVariation BEFREE In this study, we expanded on previous findings related to the 3 SNPs in the opioid receptor mu subunit (OPRM1 rs1799971), catechol-O-methyltransferase (COMT rs4680), and fatty acid amide hydrolase (FAAH rs324420) genes associated with placebo hypoalgesia and tested the effect of a 3-way interaction on placebo hypoalgesia. 31335650 2019
opioid use
CUI: C0240602
Disease: opioid use
0.010 GeneticVariation BEFREE Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain. 30211780 2019
Affective Symptoms
CUI: C0001726
Disease: Affective Symptoms
0.010 GeneticVariation BEFREE However, there has been no study investigating whether a functional four-SNP (rs6269-rs4633-rs4818-rs4680) haplotype is associated with affective symptoms over the life course. 29331705 2018
Algophobia
CUI: C0233702
Disease: Algophobia
0.010 GeneticVariation BEFREE Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia. 28968343 2018