|
Marijuana Abuse
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>COMT</i> rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP).
|
29201551 |
2017 |
|
Premature Ejaculation
|
|
0.010 |
GeneticVariation
|
BEFREE |
1 COMT gene-linked locus that was associated with PE symptoms in the present study, rs4680, is a well-documented functional polymorphism that causes a valine-to-methionine substitution.
|
29198511 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genotyped for COMT rs4680 and assessed for FER using the Ekman 60 Faces (EK60) and Emotion Hexagon (Hx) tests.
|
22222175 |
2012 |
|
Antisocial Personality Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Psychopathy trait scores were assessed [total scores and 'emotional dysfunction' (also referred to as 'affective') scores] and the MAOA 30-bp variable number of tandem repeats, SLC6A4 44-bp insertion/deletion and COMT Val158Met variants were genotyped.
|
19829167 |
2009 |
|
Anorexia Nervosa
|
|
0.060 |
GeneticVariation
|
BEFREE |
Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.
|
22366815 |
2012 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer.
|
14504192 |
2003 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer.
|
14504192 |
2003 |
|
Carcinogenesis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G>A; rs4680) that results in a lower activity enzyme, increasing susceptibility to tumorigenesis.
|
17636223 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val158Met has been found to predict performance on dopamine-mediated prefrontal tasks in healthy adults and patients with schizophrenia.
|
17924258 |
2008 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD.
|
25974322 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD.
|
25974322 |
2015 |
|
Hypersomnia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample.
|
28235603 |
2017 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene causes a 3- to 4-fold reduction in enzyme activity and has been associated with an increased risk of breast cancer.
|
11142424 |
2000 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene causes a 3- to 4-fold reduction in enzyme activity and has been associated with an increased risk of breast cancer.
|
11142424 |
2000 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer.
|
21438753 |
2011 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer.
|
21438753 |
2011 |
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals.
|
18729643 |
2008 |
|
Anxiety Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals.
|
18729643 |
2008 |
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common amino-acid polymorphism in COMT, valine-108-methionine, results in a low activity form of the enzyme which we hypothesised may influence susceptibility to IPD.
|
8941353 |
1996 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common functional polymorphism (rs4680, Val158Met) has been extensively tested for an association with schizophrenia, but with conflicting results.
|
17482701 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common Val->Met polymorphism (rs4680) in the COMT gene, associated with increased prefrontal dopamine catabolism, impairs prefrontal cognition and might increase risk for schizophrenia.
|
21999147 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A different genomic region composed of three SNPs (rs737865, rs4680, rs165599) within the COMT gene has been reported to be significantly associated with schizophrenia in Ashkenazi Jews.
|
19369177 |
2009 |
|
Impulsive Behavior
|
|
0.080 |
GeneticVariation
|
BEFREE |
A form of impulsivity, the tendency to choose immediate over delayed rewards (delay-discounting) has been associated with a single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (COMTval¹⁵⁸met; rs4680).
|
22349272 |
2012 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for breast cancer.
|
17047485 |
2006 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for breast cancer.
|
17047485 |
2006 |