|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT Val158Met (rs4680), DBH rs1611115 (also called -1021C/T or -970C/T), and MAOB rs1799836 (also called A644G) polymorphisms have been previously associated with AD.
|
31771069 |
2020 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data support the role of COMT, and particularly of rs4680, in the pathogenesis of AD.
|
31096213 |
2019 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the triple-network model is important for a diagnosis of Alzheimer's disease, our results validated the role of the dorsal-putaminal-anchored network by the catechol-O-methyltransferase Val158Met polymorphism in predicting the severity of cognitive and behavior in subjects with Alzheimer's disease.
|
28707072 |
2018 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
With the latest comprehensive searching strategy, our updated meta-analysis suggested that COMT Val158Met polymorphism could decrease the risk of AD in the Asian population, but not in the Caucasian or the overall population.
|
26810551 |
2016 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a function of APOE status, the genotypic frequencies of rs4680 in patients with AD did not differ from those in controls.
|
25491588 |
2015 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to better understand how the estrogen pathway genetic variation might affect AD onset, we conducted a case-control study of two single nucleotide polymorphisms (SNPs) of these two genes (COMT rs4680 and CYP17 rs743572) in a sample of AD patients of Italian origin.
|
25012481 |
2014 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis identified an association between AD and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPARγ Pro12Ala polymorphism.
|
24477323 |
2014 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent study reported that the functional rs4680 polymorphism within COMT gene was associated with susceptibility to AD in Caucasians.
|
24035893 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.
|
22890094 |
2012 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistically significant results were found in meta-analysis but one study reported that the rs4680 Val allele was associated with AD-related psychosis.
|
22483294 |
2012 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT (Val158 Met) polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE epsilon4 allele that proves greater in women with AD.
|
19793392 |
2009 |