rs4680, COMT;MIR4761

N. diseases: 155
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Thus, our results provide further evidence that 5-HTTLPR and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms. 25455425 2016
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We investigated and provided evidence of lower PPI: (i) in healthy pregnant women compared to healthy non-pregnant controls, (ii) in pregnant women with anxiety disorders compared to healthy pregnant women, (iii) in pregnant women with anxiety disorders using SSRI compared to un-medicated pregnant women with anxiety disorders, and (iv) in healthy pregnant women carrying the COMT Val158Met Val/Val genotype compared to Met carriers. 26189199 2016
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Applying a multilevel approach, we analyzed the main and interactive effects of the functional COMT val158met polymorphism and L-dopa (single-dose 50 mg levodopa and 12.5 mg carbidopa; double-blind, placebo-controlled design) on the emotion-potentiated (unpleasant, neutral, and pleasant IAPS pictures) startle response as an intermediate phenotype of anxiety in a sample of 100 healthy probands (f = 52, m = 48). 25510857 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Based on haplotype trend regression analysis, findings also showed that among rs737865-val158met-rs165599 haplotypes, the A-val-G (AGG) haplotype probabilities modulated positive associations of antenatal maternal anxiety with cortical thickness in the right ventrolateral prefrontal cortex and the right superior parietal cortex and precuneus. 25320962 2015
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The interaction of early life experiences with COMT val158met affects anxiety sensitivity. 24118915 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes. 23026378 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns = 476 and 409). 23475824 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815 2012
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. 22387174 2012
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 19582565 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. 19944409 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness and magnitude; eg the functional Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls. 17805313 2009
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals. 18729643 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT). 18578865 2008
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. 17146014 2007
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adolescence: results from the Victorian Adolescent Health Cohort Study. 17504250 2007
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (ie low extraversion and high neuroticism) is unlikely to be wholly accounted for by the well-studied rs4680 ('val/met') polymorphism. 15956988 2006