rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. 28608575 2018
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts. 27203226 2016
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders. 24708432 2014
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. 24389396 2014
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032 2013
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure. 22138198 2012
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene. 21231925 2011
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. 21486391 2011
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. 18384078 2008
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE Role of the COMT gene Val158Met polymorphism in mental disorders: a review. 17419009 2007
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder. 16542182 2006