rs4680, COMT;MIR4761

N. diseases: 155
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT Val158Met polymorphisms, which have been associated with risk for depression, on biases in endorsement of and memory for positive and negative adjectives. 24679392 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE No differences in the years with pain (P = 0.954), age (P = 0.740), depression (P = 0.530), severity of CTS (P = 0.744) or presence of unilateral-bilateral symptoms (P = 0.279) existed depending on the rs4680 Val158Met genotype. 24077209 2014
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Variation in the Catechol-O-Methyltransferase (COMT) gene, the Val158Met polymorphism in particular, has been extensively investigated in relation to clinical phenotypes of depression and, in parallel, neurocognitive processes. 23792050 2014
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. 23475824 2013
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. 22387174 2012
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study. 20828831 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Although the current study found no association between COMT Val(158)Met polymorphism on a number of clinical neuropsychological tests that are typically found to be sensitive to depression, differential effects of the COMT Val(158)Met polymorphism on dopamine transmission in psychiatric and non-psychiatric populations may be further clarified by clinical research with neuroscience-based paradigms that segregate cognitive tasks into component processes with precise neural substrates, particularly with respect to the complex functions of the prefrontal cortex. 19296553 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE There is strong evidence for a genetic contribution to the pathogenesis of depression, with the functional catechol-O-methyltransferase (COMT) val158met polymorphism having been suggested as a potential susceptibility factor. 19309019 2010
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE We found that the COMT val158met polymorphism was not associated with 4-week fluoxetine therapeutic response; however, association analysis showed that patients with the COMT(Val/Val) genotype had poorer responses in the eighth week (CLUMP T1 P=0.020) and consistently showed significantly smaller reductions in HAM-D(21) scores in the eighth week (P=0.027). 18533273 2009
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT). 18578865 2008
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. 17522626 2008