|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis identified an association between fibromyalgia risk and the COMT Val158Met polymorphism as well as the FIQ score in fibromyalgia patients.
|
24951880 |
2015 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016).
|
24762091 |
2014 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results provide initial evidence of a link between Val158Met polymorphism and dysfunctions in the SNS and humoral immune system in women with FMS.
|
24503977 |
2014 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients.
|
22528689 |
2013 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes.
|
23025981 |
2012 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680 (Val158Met).
|
22722321 |
2012 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients.
|
21120493 |
2012 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process and suggest that genetic variation in the val(158)met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition.
|
21130573 |
2011 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed an association between FM and the COMT val(158) met polymorphism in a dose response effect of the COMT genotype and the number of pressure points reported.
|
20074440 |
2010 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients.
|
19464960 |
2009 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS.
|
18196244 |
2008 |
|
Fibromyalgia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Spanish patients, there was a significant association between three SNPs (rs6269, rs4818, and rs4680) and the presence of FM when compared with healthy controls.
|
17961261 |
2007 |