rs4680, COMT;MIR4761

N. diseases: 155
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In conclusion, COMT rs4680 and OPRK rs6473799 polymorphisms seem to be associated with pain sensitivity. 27061127 2017
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE In the overall sample, rs4633 and rs4680 were significantly associated with morphine use, whereas rs4818 was associated with time-averaged pain scores. 25963335 2016
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heterogeneity in SCD, as suggested by the different rates of acute pain crisis. 25102390 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain. 25218601 2015
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE There was no association between any of the tested pain phenotypes and SNP rs4680. 24343288 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome. 24077209 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery. 23210659 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. 24290452 2014
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. 23025981 2013
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients. 22528689 2013
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE COMT val158met polymorphism and neural pain processing. 22247753 2012
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. 21898113 2012
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. 22132136 2012
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP that reduces enzyme activity, has previously been linked to pain sensitivity. 22337560 2012
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain. 21049025 2011
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process and suggest that genetic variation in the val(158)met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition. 21130573 2011
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation. 20509977 2010
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism. 18548001 2009
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence pain sensitivity in human experimental pain and the efficacy for morphine in cancer pain treatment. 19094200 2009
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. 19547755 2009
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val(158)met) position, designated as low (LPS), average (APS), and high pain sensitive (HPS), are associated with experimental pain sensitivity and risk of developing chronic musculoskeletal pain conditions. 19365560 2009
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE COMT Val158Met and thermal pain measures were not related. 19464960 2009
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. 16688411 2006
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE This suggests that the val(158)met SNP plays a primary role in variation in temporal summation of pain, but that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity. 16837133 2006
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE A single nucleotide polymorphism (Val158Met) of COMT leads to a three to four fold reduction in the activity of the enzyme and has been associated to modifications in the response to a pain stressor. 15862471 2005