rs4680, COMT;MIR4761

N. diseases: 155
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. 24389396 2014
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032 2014
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure. 22138198 2013
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. 22070166 2012
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE On the other hand, preferential transmission of COMT rs4680 A allele and A-A haplotype (P<0.05) was observed specifically in male IID probands without any behavioral problem. 21609749 2012
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene. 21231925 2011
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE COMT Val158Met genotype as a risk factor for problem behaviors in youth. 20643317 2010
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.080 GeneticVariation BEFREE The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. 18384078 2008