rs4680, COMT;MIR4761

N. diseases: 249
Disease: Chronic low back pain ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Chronic low back pain
CUI: C0457949
Disease: Chronic low back pain
0.020 GeneticVariation BEFREE Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing. 31269327 2019
Chronic low back pain
CUI: C0457949
Disease: Chronic low back pain
0.020 GeneticVariation BEFREE In the present study, we first evaluated the association between COMT rs4680 and the analgesic response to intrathecal morphine in patients with chronic low back pain to provide confirmation of previously reported positive findings. 23773341 2013