rs4680, COMT;MIR4761

N. diseases: 249
Disease: Anxiety state ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety state
CUI: C0700613
Disease: Anxiety state
0.010 GeneticVariation BEFREE A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of the catechol-O-methyltransferase (COMT) gene leads to a three- to fourfold difference in enzymatic activity and clinical and animal studies suggest a role in anxiety states like panic disorder. 11950461 2002