Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE COMT Val158Met genotype data were also obtained from children with ADHD. 28687733 2017
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE COMT Val158Met genotype data were also obtained for the ADHD group. 26576742 2017
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE COMT Val158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls. 26560848 2016
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE We demonstrated that white matter connectivity in youth with ADHD is associated with COMT Val158Met genotypes. 25201318 2015
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE This study provides the first evidence of a modulation of ADHD-related GM volume alterations by Val158Met in two key regions, possibly mediating the relationship between Val158Met polymorphism and antisocial behaviour in children with ADHD. 25495556 2015
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Although the reported nominally significant associations did not stay significant after correcting for multiple testing, our results support previous findings about the possible involvement of the COMT (Val(158)-Met) polymorphism in the treatment response to methylphenidate in children with ADHD. 24763183 2014
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were analyzed for effects on behavioral and neural correlates of prefrontal response control (NoGo-anteriorization, NGA) using a Go-NoGo task and electroencephalography (114 controls and 181 patients with attention-deficit/hyperactivity disorder). 22617852 2013
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Studies have associated the rs4680 genotype with impulsivity as a symptom in attention deficit hyperactivity disorder and substance abuse. 23440431 2013
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). 22270685 2012
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on oppositional symptoms in boys with attention-deficit/hyperactivity disorder. 21550019 2011
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Since our previous association studies between attention deficit hyperactivity disorder (ADHD) and these two functional polymorphisms consistently showed the low activity alleles were preferentially transmitted to inattentive ADHD boys, the goal of the present study was to test the hypothesis that the interaction between COMT Val158Met and MAOA-uVNTR may affect the intelligence in a clinical sample of Chinese male ADHD subjects (n = 264). 19941049 2010
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. 19997043 2010
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Our results directly link variation in genes putatively influencing dopamine signaling in the prefrontal cortex (COMT(Val158Met)) and the striatum (DAT1(10/6)) with discounting rates in a hypothetical task (but not a real-time task) and self-ratings of trait impulsivity in ADHD-CT and healthy controls. 20736997 2010
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE The aim of the present study was to assess the COMT Val(158)Met SNP as a risk factor for attention-deficit/hyperactivity disorder</span> (A</span>DHD), ADHD symptom severity and co-morbid conduct disorder (CD) in 166 children with ADHD. 19946713 2010
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE We therefore hypothesized that analysis of haplotypes could reveal more about the association between COMT and ADHD symptoms than the Val158Met polymorphism alone. 18802928 2009
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Our results did not indicate substantial involvement of these two VNTRs in ADHD, however, both the case-control and the pharmacogenetic analyses showed significant role of the high activity Val-allele of cathecol-O-methyltransferase (COMT) Val158Met polymorphism in our ADHD population. 18214865 2008
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 48 base pair (bp) repeat, DRD4 120 bp duplicated repeat, SLC6A3 (DAT1) 40 bp variable number of tandem repeats (VNTR), and COMT Val158Met). 17886261 2008
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE We present replicated evidence that the COMT valine/methionine polymorphism at codon 158 (COMT Val158Met) was associated with phenotypic variation among children with ADHD. 18250258 2008
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals. 17949513 2008
Attention deficit hyperactivity disorder
0.100 GeneticVariation BEFREE Moreover, a functional Val158Met polymorphism in COMT that alters the activity of the encoded protein has been strongly implicated in frontal lobe function, with the high activity Valine allele being associated with poorer performance, and ADHD is thought to involve fronto-striatal pathways. 15635644 2005