We found converging evidence of association with PD on 12q24 (rs4964469, combined P = 2.4 × 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 × 10(-6)), previously reported in Japanese data.
We found that Rep1, rs356165, and rs11931074 in SNCA gene; G2385R in LRRK2 gene; rs4698412 in BST1 gene; rs1564282 in PARK17; and L444P in GBA gene were associated with PD with adjustment of sex and age (p < 0.05) in the analysis of 16 variants.
Significant association was also detected between the allelic, dominant, and recessive models of rs4698412 and PD risk in Asian populations (allelic model: <i>P</i><0.00001, OR [95% CI]=1.22 [1.16-1.29]; dominant model: <i>P</i><0.00001, OR [95%CI]=1.35 [1.20-1.52]; recessive model; <i>P</i>=0.0003, OR [95% CI]=1.30 [1.13-1.50]).