rs4779584, None

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035). 25873010 2016
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE This meta-analysis demonstrated that the rs4779584 and rs10318 polymorphism at 15q13.3 is a risk factor associated with increased CRC/CRA susceptibility, but these associations vary in different ethnic populations. 25475391 2015
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE rs4939827, rs4779584, and rs10795668 may contribute to the risk of CRC in the Korean population as well as in European populations. 23875689 2015
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer. 24586997 2014
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASDB Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber). 22367214 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASCAT Meta-analysis of new genome-wide association studies of colorectal cancer risk. 21761138 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASDB Meta-analysis of new genome-wide association studies of colorectal cancer risk. 21761138 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)). 21655089 2011
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASCAT A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 18372905 2008
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation BEFREE In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)). 18084292 2008
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASDB A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 18372905 2008
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.870 GeneticVariation GWASDB Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008