rs4880, SOD2

N. diseases: 131
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6). 29110844 2017
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE However, no association between the MnSOD Val(16)Ala polymorphism and lung cancer was detected among ETS-exposed individuals (OR 1.6, P = 0.147), although the lung cancer group had significantly lower MnSOD activity than the chronic or passive smoker groups (P = 0.03). 23928928 2014
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that SOD2 C47T polymorphism was significantly associated with lung cancer</span> in both East Asians and Caucasians. 23990443 2014
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE A review was conducted of 136 patients treated with radiation therapy for lung cancer between 2001 and 2007, and who had prior genotyping of functional single-nucleotide polymorphisms in oxidative stress genes including superoxide dismutase 2 (SOD2; rs4880) and methylene tetrahydrofolate reductase (MTHFR; rs1801131, rs1801133). 22144047 2012
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer. 18420450 2008
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer. 18258609 2008
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong. 17409931 2006
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.080 GeneticVariation BEFREE We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China. 15284179 2004