rs4986790, TLR4

N. diseases: 223
Disease: Tuberculosis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. 20002809 2010
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism. 17545720 2007
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE In conclusion, our data suggest that TLR4 (D299G and T399I) and TNF (-308G/A) genetic polymorphisms may influence the risk of developing tuberculosis after exposure to Mycobacterium. 26774366 2016
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE Our data suggest that TLR4 Asp299Gly has no influence on monocyte LPS responses or susceptibility to TB in Gambians and could be an ancient neutral polymorphism. 15525557 2004
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE We describe an independent association between TLR4 Asp299Gly SNP and active TB in Caucasian Mediterranean HIV-infected patients. 20226000 2010
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.060 GeneticVariation BEFREE The present meta-analysis suggests that TLR4 gene Asp299Gly and Thr399Ile polymorphisms are not associated with the susceptibility of tuberculosis. 23200920 2013