Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 Asp299Gly and TLR2 -196 to -174del showing associations with GC in an ethnic-specific manner.
|
23565226 |
2013 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increase risk of gastric cancer in the Helicobacter pylori-positive population (G allele vs. A allele: OR=2.01, 95%CI: 1.22, 3.31).
|
24007538 |
2013 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in terms of stratified analyses by cancer type for SNP rs4986790, significantly elevated risk was observed to be associated with G allele in gastric cancer and 'other cancers'.
|
23084080 |
2013 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developing gastric mucosal atrophy in H. pylori infected patients more than 61 years of age, and these genotypes may reduce the risk of intestinal type gastric cancer and TLR4 Asp299Gly, Thr399Ile are very rare in the Japanese population.
|
19847953 |
2007 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population.
|
17462092 |
2007 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
|
18755634 |
2008 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.
|
22468087 |
2012 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms were reported to be a risk factor of gastric carcinoma or its precursors in Caucasian and Indian population, but these polymorphisms are absent in Japanese.
|
19191896 |
2009 |
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes.
|
18826495 |
2008 |