rs4986790, TLR4

N. diseases: 223
Disease: Malaria ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malaria
CUI: C0024530
Disease: Malaria
0.030 GeneticVariation BEFREE Present study evaluated the importance of rs4986790 polymorphism of <i>TLR4</i> gene in susceptibility towards malaria, clinical outcomes of the disease and responsible species of malaria. 29922617 2018
Malaria
CUI: C0024530
Disease: Malaria
0.030 GeneticVariation BEFREE TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). 24282567 2013
Malaria
CUI: C0024530
Disease: Malaria
0.030 GeneticVariation BEFREE Genetic and functional studies are compatible with a model in which the nonsynonymous polymorphism Asp299Gly has evolved as a protective allele against malaria, explaining its high prevalence in subSaharan Africa. 17925445 2007