rs4986790, TLR4

N. diseases: 146
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Septicemia
CUI: C0036690
Disease: Septicemia
0.050 GeneticVariation BEFREE Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. 25454804 2015
Septicemia
CUI: C0036690
Disease: Septicemia
0.050 GeneticVariation BEFREE In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. 21968286 2012
Septicemia
CUI: C0036690
Disease: Septicemia
0.050 GeneticVariation BEFREE Six haplotype-tagging SNPs in the TLR4 gene were subsequently examined to analyze their influence on TLR4 A896G SNPs relationship to sepsis severity. 19131814 2009
Septicemia
CUI: C0036690
Disease: Septicemia
0.050 GeneticVariation BEFREE To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis). 12807489 2003
Septicemia
CUI: C0036690
Disease: Septicemia
0.050 GeneticVariation BEFREE Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. 12404174 2002