rs4986790, TLR4

N. diseases: 223
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. 27958344 2016
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. 25454804 2015
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). 25427560 2015
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. 21968286 2012
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE The odds ratio for the association of Asp299Gly polymorphism with sepsis</span> risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57). 22537674 2012
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE Six haplotype-tagging SNPs in the TLR4 gene were subsequently examined to analyze their influence on TLR4 A896G SNPs relationship to sepsis severity. 19131814 2009
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. 18034244 2008
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis). 12807489 2003
Septicemia
CUI: C0036690
Disease: Septicemia
0.090 GeneticVariation BEFREE Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. 12404174 2002