Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE Altered Th17 Cytokine Expression in Helicobacter pylori Patients with TLR4 (D299G) Polymorphism. 26853914 2016
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the pathogenesis of Helicobacter pylori related gastroduodenal diseases in relation to gastric secretion and inflammation. 26161647 2015
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increase risk of gastric cancer in the Helicobacter pylori-positive population (G allele vs. A allele: OR=2.01, 95%CI: 1.22, 3.31). 24007538 2013
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score. 17171451 2007
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE A Toll-like receptor-4 (TLR-4) Asp299Gly and Thr399Ileu substitution reduces responsiveness to Helicobacter pylori (H. pylori) lipopolysaccharide. 18082569 2007
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.060 GeneticVariation BEFREE We genotyped 87 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, 594 Helicobacter pylori positive controls and 358 healthy blood donors to investigate an association of TLR4 Asp299Gly in the development of gastric MALT lymphoma. 16019531 2005