rs4986790, TLR4

N. diseases: 146
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carotid Atherosclerosis
CUI: C0577631
Disease: Carotid Atherosclerosis
0.040 GeneticVariation BEFREE A total of 3000 individuals from the prospective community-based Carotid Atherosclerosis Progression Study (CAPS) were genotyped for single nucleotide polymorphisms: TLR2 (Arg753Gln, -16934 A/T) and TLR4 (D299G, T399I). 17332447 2007
Carotid Atherosclerosis
CUI: C0577631
Disease: Carotid Atherosclerosis
0.040 GeneticVariation BEFREE The presence of the D299G and T399I polymorphisms of the TLR-4 gene does not play a major role on the progression of carotid atherosclerosis. 15953129 2005
Carotid Atherosclerosis
CUI: C0577631
Disease: Carotid Atherosclerosis
0.040 GeneticVariation BEFREE The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces responsiveness to lipopolysaccharide and has been associated with reduced incidence and slower progression of carotid atherosclerosis. 12957699 2004
Carotid Atherosclerosis
CUI: C0577631
Disease: Carotid Atherosclerosis
0.040 GeneticVariation BEFREE This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia. 15258789 2004