rs4986790, TLR4

N. diseases: 146
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 Asp299Gly and TLR2 -196 to -174del showing associations with GC in an ethnic-specific manner. 23565226 2013
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection. 22468087 2012
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes. 18826495 2009
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms were reported to be a risk factor of gastric carcinoma or its precursors in Caucasian and Indian population, but these polymorphisms are absent in Japanese. 19191896 2009
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis. 18755634 2008
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.060 GeneticVariation BEFREE Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer. 17462092 2007