Thus, the aim of this study was to evaluate the influence of the <i>TLR4</i> A896G (rs4986790), <i>TLR4</i> C1196T (rs4986791), <i>CD14</i> C-260T (rs2569190), <i>RANKL</i> (<i>TNFSF11</i>, rs2277438), and <i>OPG</i> (<i>TNFSF11B</i> C163T, rs3102735) polymorphisms in periodontitis.
Evaluating the association of TLR4 polymorphisms (Asp299 and Thr399Ile) with the occurrence of periodontitis and its two clinical types: chronic (CP) and aggressive (AgP) among Caucasians.
Meta-analysis of the TLR4 Asp299Gly and Thr399Ile polymorphisms showed no association between periodontitis and the TLR4 299Asp allele in all study subjects (OR=0.984, 95% CI=0.761-1.271, p=0.900; OR=1.030, 95% CI=0.748-1.418, p=0.854).
The prevalence of TLR2 Arp677Trp polymorphism seemed to be rather high, while that of TLR4 Asp299Gly and Thr399Ile polymorphisms seemed to be rather low in the Chinese population, which did not permit any conclusion regarding its effects on periodontitis.