rs4986791, TLR4

N. diseases: 182
Disease: Aggressive Periodontitis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Aggressive Periodontitis
CUI: C0031106
Disease: Aggressive Periodontitis
0.030 GeneticVariation BEFREE The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP). 26079505 2015
Aggressive Periodontitis
CUI: C0031106
Disease: Aggressive Periodontitis
0.030 GeneticVariation BEFREE All case-control studies evaluating the TLR4 Asp299Gly and Thr399Ile polymorphisms in chronic or aggressive periodontitis were identified. 19426173 2009
Aggressive Periodontitis
CUI: C0031106
Disease: Aggressive Periodontitis
0.030 GeneticVariation BEFREE One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A). 18983635 2008