rs4986791, TLR4

N. diseases: 182
Disease: Gallbladder Carcinoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Gallbladder Carcinoma
CUI: C0235782
Disease: Gallbladder Carcinoma
0.030 GeneticVariation BEFREE Single locus analysis by logistic regression showed association of MSH2 IVS1+9G>C (rs2303426), ERCC2 Asp312Asn (rs1799793), OGG1 Ser326Cys (rs1052133), OGG1 IVS4-15C>G (rs2072668), CASP8 -652 6N ins/del (rs3834129), PTGS2 -1195G>A (rs689466), PTGS2 -765G>C (rs20417), TLR4 Ex4+936C>T (rs4986791) and TLR2 -196 to -174del polymorphisms with GBC risk. 21283657 2011
Gallbladder Carcinoma
CUI: C0235782
Disease: Gallbladder Carcinoma
0.030 GeneticVariation BEFREE Thr399Ile also may be connected with gallbladder cancer, and both of these polymorphisms apparently have no impact on risk of prostate cancer. 21081146 2011
Gallbladder Carcinoma
CUI: C0235782
Disease: Gallbladder Carcinoma
0.030 GeneticVariation BEFREE The TLR4 Ex4+936C >T polymorphism (g.14143C>T; rs4986791) was also found to be significantly associated with the overall higher risk of GBC under a dominant mode of inheritance (OR=1.96; 95% CI=1.11-2.26; P(trend)=0.021). 20492496 2010