|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that TLR4 T399I polymorphism is moderately associated with susceptibility to CD, and more studies are needed to confirm our conclusion.
|
29421805 |
2018 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between TLR4 Thr399Ile polymorphisms and CD risk were found only in the allele and dominant models.
|
26023918 |
2015 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms of TLR4 (D299G, T399I) gene were genotyped by PCR-RFLP in 199 UC, 46 Crohn's disease (CD) patients, and 201 healthy controls.
|
23470644 |
2013 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.
|
22918682 |
2013 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.
|
19664207 |
2009 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.
|
15973118 |
2005 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Asp299Gly and Thr399Ile variants do not show an association with CD, UC, or IBD as a group, indicating that these polymorphisms are likely not the causal ones.
|
15905704 |
2005 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
One SNP (rs4986791 in the TLR-4 locus) and 2 SNPs (rs6785049 in the Pregnane-x-receptor gene and rs10500264 in the SLCA10 gene) were associated with a change in albumin and hemoglobin over time respectively in our IBD cohort.
|
30423580 |
2019 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4-Thr399Ile variant was strongly associated with susceptibility to IBD, whereas TLR4-Asp299Gly seems to play a role in the clinical expression of UC.
|
29055077 |
2017 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4 Thr399Ile polymorphism was associated with UC risk in pooled results as well as subgroup analysis of high quality publications assessing Caucasians, in allele and dominant models.
|
26023918 |
2015 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
TLR4 Thr399Ile may be associated with IBD susceptibility in Caucasians only.
|
26023918 |
2015 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
T399I showed significant association with UC (P=0.006) but not with CD patients.
|
23470644 |
2013 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.
|
22918682 |
2013 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp polymorphisms may not be associated with IBD in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.
|
23239925 |
2012 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.
|
22468087 |
2012 |