Gestational Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2.
|
19002430 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of T2DM in females (P<0.005), but not in males (P>0.005).
|
21368910 |
2011 |
Insulin measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
Glucose tolerance test
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
Coronary heart disease
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
18372903 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
18372903 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
Neural Tube Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association was found between the other four single nucleotide polymorphisms (LEPR rs1137100, HK1 rs748235, HHEX rs5015480, KCNQ1 rs2237892) and NTD risk.
|
25369983 |
2015 |
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism.
|
20503258 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results provide clarification to the significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes.
|
23166797 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation.
|
23298195 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population.
|
28067832 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The finding revealed the all measured inheritance models of rs1111875G/A and of rs5015480C/T variants dramatically increase the risk of T2D while another polymorphism (rs7923837A/G) was not associated with risk/protective role in T2D.
|
31237015 |
2019 |
Gestational Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
The HHEX gene rs5015480 C allele may be a risk allele of GDM that is associated with increased BMI during pregnancy.
|
27684496 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
Gestational Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs rs5015480 [odds ratio (OR) = 1.46 (95% CI 1.20-1.77), p = 2.0 x 10(-4)], rs7923837 [OR = 1.40 (95% CI 1.17-1.68), p = 2.0 x 10(-4)] and rs1111875 [OR = 1.30 (95% CI 1.11-1.52), p = 0.0013] in HHEX were significantly associated with type 2 diabetes with the same direction as previously reported.
|
17928989 |
2007 |