|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population.
|
30467975 |
2019 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this cohort, rs5215 and rs5219 of KCNJ11 were not significant predictors of incident diabetes nor effect modifiers of the association between serum K and incident diabetes.
|
30169531 |
2018 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, the E23K polymorphism (rs5219) was not associated with type 1 or 2 diabetes mellitus in the studied population.
|
28387875 |
2017 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the T2DM ins+ group, E23K-AA carriers had lower onset age and duration of diabetes and higher BMI than GG carriers, and A190A-TT carriers had higher SBP than CC carriers (all p < 0.05).
|
25725792 |
2015 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) Association in Russian Diabetes Mellitus 2 Type Cohort and Meta-Analysis.
|
25955821 |
2015 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Following subgroup analysis of individuals with and without diabetes based on BMI, a nominal significant association was observed between type 2 diabetes in the presence of obesity and E23K genotype in the recessive model (p = 0.03).
|
24460047 |
2014 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation.
|
24996284 |
2014 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.
|
22264780 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The KCNJ11 E23K and ABCC8 exon 31 variants contribute to susceptibility to T2D diabetes, glucose intolerance and altered insulin secretion in a Russian population.
|
18758683 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, in generalized linear model analyses, the E23K variant was significantly associated with increased HbA(1c) levels (adjusted p=0.04) independent of age, sex, body mass index, diabetes duration and sulfonylurea dose.
|
19214942 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort.
|
17977958 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes.
|
17259403 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
KCNJ11 E23K was significantly associated with an increased diabetes risk (odds ratio 1.26, 95% CI 1.03-1.53) while HNF4A P2 promoter polymorphisms were associated with a moderately increased risk at borderline significance.
|
17894829 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriers of the predisposing Kir6.2 E23K K allele showed no increased risk of either type of diabetes mellitus development.
|
17976307 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the E23K variant rs5219 in KCNJ11 showed no association with diabetes in Japanese (for the K allele, odds ratio [OR] 1.08 [95% CI 0.97-1.21], P = 0.15), 95% CI around the OR overlaps in meta-analysis of European populations, suggesting that our results are not inconsistent with the previous studies.
|
16873704 |
2006 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results confirm that E23K increases risk of type 2 diabetes and show that large-scale association studies are important for the identification of diabetes susceptibility alleles.
|
12540637 |
2003 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites, and a recent in vitro study of the E23K variant suggests that the association to diabetes might be explained by a slight inhibition of serum insulin release.
|
12540638 |
2003 |